Immunohistochemical Identification of an Extracellular Matrix Scaffold that Microguides Capillary Sprouting In Vivo
نویسندگان
چکیده
منابع مشابه
Tensional forces in fibrillar extracellular matrices control directional capillary sprouting.
During angiogenesis, anastomosing capillary sprouts align to form complex three-dimensional networks of new blood vessels. Using an endothelial cell spheroid model that was developed to study endothelial cell differentiation processes, we have devised a novel collagen gel-based three-dimensional in vitro angiogenesis assay. In this assay, cell number-defined, gel-embedded endothelial cell spher...
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Submit Manuscript | http://medcraveonline.com of polysaccharides and proteins, such as collagens, proteoglycans and glycoproteins that are essential in tissue engineering [3]. Cellular interactions with the ECM are known to play a critical role in providing structural support to cells, directing cell function, and regulating development, homeostasis, and repair of a variety of tissues [4-8]. EC...
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Small intestinal submucosa (SIS) has been successfully used to treat a variety of damaged or diseased tissues in human patients. As a biologic scaffold, SIS stimulates repair of damaged or diseased tissues and organs with tissue that is similar in structure and function to the material it was meant to replace. To meet clinical safety requirements, biologic materials from animal tissues must und...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2004
ISSN: 0022-1554,1551-5044
DOI: 10.1369/jhc.4a6250.2004